1140-166 Enhancing arteriogenesis increases atherosclerosis and reducing atherosclerosis reduces arteriogenesis: Demonstration of the concept in mice
نویسندگان
چکیده
منابع مشابه
Plaque angiogenesis versus compensatory arteriogenesis in atherosclerosis.
Many atherosclerotic lesions are vascularized by a network of capillaries that arise from the adventitial vasa vasorum.1 These capillaries may be important regulators of plaque instability. Reflecting their inflammatory microenvironment, the capillaries are immature endothelial tubes with disorganized branching, fragile and prone to rupture. The accumulation of erythrocytes after intraplaque he...
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BACKGROUND Fibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin receptor α5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which inhibits anti-inflammatory cyclic adenosine monophosphate and protein kinase A. Replacing the α5 ...
متن کاملDelayed arteriogenesis in hypercholesterolemic mice.
BACKGROUND Hypercholesterolemia has been reported to inhibit ischemia-induced angiogenesis. To address its effects on arteriogenesis, we investigated arterial growth in hypercholesterolemic low-density lipoprotein receptor(-/-)/ApoB-48(-/-) (HCE) mice. METHODS AND RESULTS The extent and the time course of arteriogenesis after femoral artery ligation was evaluated in HCE and strain-matched con...
متن کاملAerobic exercise training reduces inflammatory markers involved in atherosclerosis
Introduction: Adipose tissue and inflammatory factors play important role in occurrence of atherosclerosis in overweight women. The present study aimed to investigate the effect of 8 weeks of aerobic exercise training on risk factors involved in atherosclerosis in overweight women. Materials and methods: For this, fourteen overweight women (mean ± standard deviation: body mass index 28....
متن کاملthe relationship between academic self-concept and academic achievement in english and general subjects of the students of high school
according to research, academic self-concept and academic achievement are mutually interdependent. in the present study, the aim was to determine the relationship between the academic self-concept and the academic achievement of students in english as a foreign language and general subjects. the participants were 320 students studying in 4th grade of high school in three cities of noor, nowshah...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2004
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(04)92145-6